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Issue 5, 2015
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Structural characterization and immunomodulatory activity of a new heteropolysaccharide from Prunella vulgaris

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Abstract

A new heteropolysaccharide, here called P1, was isolated from the fruit clusters of Prunella vulgaris using a hot water extraction method. Chemical and physical analyses indicated that P1 had a spherical conformation with an average molecular weight of 1750 kDa and consisted of arabinose (28.37%), xylose (54.67%), mannose (5.61%), glucose (5.46%), and galactose (5.89%). The main types of P1 linkages were proved to be (1→5)-linked α-L-Ara, (1→)-linked α-L-Ara, (1→3)-linked α-D-xyl, (1→3)-linked β-D-Gal, (1→3,6)-linked β-D-Gal, (1→3,6)-linked α-D-Man and (1→6)-linked α-D-Glc according to the periodate oxidation-Smith degradation and NMR analyses. P1 could significantly enhance the secretion of NO, TNF-α, and IL-6 in murine RAW 264.7 cells, involving the toll-like receptor 2 (TLR2), TLR4 and complement receptor 3 (CR3). Further studies showed that P1 exhibited stable immune activities in the pH range of 4.0–10.0 and below 121 °C. The results suggested that P1 could be used as a potent immunomodulatory agent in functional foods and pharmacological fields.

Graphical abstract: Structural characterization and immunomodulatory activity of a new heteropolysaccharide from Prunella vulgaris

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Publication details

The article was received on 15 Nov 2014, accepted on 15 Mar 2015 and first published on 16 Mar 2015


Article type: Paper
DOI: 10.1039/C4FO01039F
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Food Funct., 2015,6, 1557-1567

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    Structural characterization and immunomodulatory activity of a new heteropolysaccharide from Prunella vulgaris

    C. Li, L. You, X. Fu, Q. Huang, S. Yu and R. H. Liu, Food Funct., 2015, 6, 1557
    DOI: 10.1039/C4FO01039F

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