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Volume 177, 2015
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Pluronic copolymer encapsulated SCR7 as a potential anticancer agent

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Abstract

Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity of SCR7 decreases its bioavailability which is a major setback in the utilization of this compound as a therapeutic agent. In order to circumvent the drawback of SCR7, we prepared a polymer encapsulated form of SCR7. The physical interaction of SCR7 and Pluronic® copolymer is evident from different analytical techniques. The in vitro cytotoxicity of the drug formulations is established using the MTT assay.

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Submitted
15 Sep 2014
Accepted
04 Nov 2014
First published
21 Jan 2015

Faraday Discuss., 2015,177, 155-161
Article type
Paper

Pluronic copolymer encapsulated SCR7 as a potential anticancer agent

F. John, J. George, M. Srivastava, P. A. Hassan, V. K. Aswal, Subhas. S. Karki and Sathees. C. Raghavan, Faraday Discuss., 2015, 177, 155
DOI: 10.1039/C4FD00176A

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