Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Volume 179, 2015
Previous Article Next Article

Measuring induction times and crystal nucleation rates

Author affiliations

Abstract

A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of nucleation if the number of nuclei formed is approaching 1 per vial. Accurate heterogeneous crystal nucleation rates were determined from the induction time distributions on a 1 ml scale for racemic diprophylline in two solvents. The difference in nucleation behaviour in the two solvents originates from the energy barrier for nucleation, which is much higher in the solvent in which induction times are much longer. In addition the pre-exponential factor for the crystal nucleation rate in both solvents is rather low compared to predictions using Classical Nucleation Theory. Unfortunately, concentration and surface characteristics of the effective heterogeneous particles are not known which clouds a further molecular interpretation.

Back to tab navigation

Associated articles

Article information


Submitted
22 Nov 2014
Accepted
27 Jan 2015
First published
27 Jan 2015

Faraday Discuss., 2015,179, 199-214
Article type
Paper
Author version available

Measuring induction times and crystal nucleation rates

C. Brandel and J. H. ter Horst, Faraday Discuss., 2015, 179, 199
DOI: 10.1039/C4FD00230J

Social activity

Search articles by author

Spotlight

Advertisements