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Issue 36, 2015
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A cyclometallated fluorenyl Ir(iii) complex as a potential sensitiser for two-photon excited photodynamic therapy (2PE-PDT)

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Abstract

A new Ir(III) cyclometallated complex bearing a fluorenyl 5-substituted-1,10-phenanthroline ligand ([Ir(ppy)2(L1)][PF6], ppy = 2-phenylpyridine) is presented which exhibits enhanced triplet oxygen sensing properties. The efficacy of this complex to act as a photosensitiser for altering the morphology of C6 Glioma cells that represent malignant nervous tumours has been evaluated. The increased heavy metal effect and related spin–orbit coupling parameters on the photophysical properties of this complex are evidenced by comparison with Ru(II) analogues. The complex [Ir(ppy)2(L1)][PF6] is shown to exhibit relatively high two-photon absorption efficiencies for the lowest energy MLCT electronic transitions with two-photon absorption cross sections that range from 50 to 80 Goeppert–Mayer units between 750 to 800 nm. Quantum yields for the complex were measured up to 23% and the Stern–Volmer quenching constant, KSV was determined to be 40 bar−1 in acetonitrile solution, confirming the high efficiency of the complex as a triplet oxygen sensitiser. Preliminary in vitro experiments with C6 Glioma cells treated with [Ir(ppy)2(L1)][PF6], show that the complex is an efficient sensitizer for triplet oxygen, producing cytotoxic singlet oxygen (1O2) by two-photon excitation at 740 nm resulting in photodynamic effects that lead to localised cell damage and death.

Graphical abstract: A cyclometallated fluorenyl Ir(iii) complex as a potential sensitiser for two-photon excited photodynamic therapy (2PE-PDT)

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Supplementary files

Article information


Submitted
17 May 2015
Accepted
10 Aug 2015
First published
10 Aug 2015

This article is Open Access

Dalton Trans., 2015,44, 16127-16135
Article type
Paper
Author version available

A cyclometallated fluorenyl Ir(III) complex as a potential sensitiser for two-photon excited photodynamic therapy (2PE-PDT)

E. M. Boreham, L. Jones, A. N. Swinburne, M. Blanchard-Desce, V. Hugues, C. Terryn, F. Miomandre, G. Lemercier and L. S. Natrajan, Dalton Trans., 2015, 44, 16127
DOI: 10.1039/C5DT01855B

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