A highly selective fluorescent ‘turn-on’ chemosensor for Zn2+ based on a benzothiazole conjugate: their applicability in live cell imaging and use of the resultant complex as a secondary sensor of CN−

Nilesh Khairnar; Kundan Tayade; Suban K. Sahoo; Banashree Bondhopadhyay; Anupam Basu; Jasminder Singh; Narinder Singh; Vikas Gite; Anil Kuwar

doi:10.1039/C4DT03247K

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A highly selective fluorescent ‘turn-on’ chemosensor for Zn²⁺ based on a benzothiazole conjugate: their applicability in live cell imaging and use of the resultant complex as a secondary sensor of CN⁻†

Nilesh Khairnar,^a Kundan Tayade,^a Suban K. Sahoo,^b Banashree Bondhopadhyay,^c Anupam Basu,^c Jasminder Singh,^d Narinder Singh,^d Vikas Gite*^a and Anil Kuwar*^a

Author affiliations

* Corresponding authors

^a School of Chemical Sciences, North Maharashtra University, Jalgaon-425001, MS, India
E-mail: kuwaras@gmail.com

^b Department of Applied Chemistry, SV National Institute Technology, Surat-395007, Gujarat, India

^c Molecular Biology and Human Genetics Laboratory, Department of Zoology, The University of Burdwan, Burdwan, West Bengal, India

^d Department of Chemistry, Indian Institute Technology, Ropar-140001, Panjab, India

Abstract

A benzothiazole derivative linked “off-on” multi-responsive and selective chemosensor 3 has been synthesized and evaluated for cation recognition properties. The receptor 3 shows a high sensitivity and selectivity for Zn²⁺ through a ‘turn-on’ fluorescence response over the other tested cations with a detection limit as low as 0.67 μM. The receptor 3 was successfully applied for the detection of Zn²⁺ in live HeLa cells. Then, the Zn²⁺ complex of receptor 3 was also used for cyanide detection and recognition.

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DOI: https://doi.org/10.1039/C4DT03247K
Article type: Paper
Submitted: 21 Oct 2014
Accepted: 06 Nov 2014
First published: 12 Nov 2014

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Dalton Trans., 2015,44, 2097-2102

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A highly selective fluorescent ‘turn-on’ chemosensor for Zn²⁺ based on a benzothiazole conjugate: their applicability in live cell imaging and use of the resultant complex as a secondary sensor of CN⁻

N. Khairnar, K. Tayade, S. K. Sahoo, B. Bondhopadhyay, A. Basu, J. Singh, N. Singh, V. Gite and A. Kuwar, Dalton Trans., 2015, 44, 2097 DOI: 10.1039/C4DT03247K

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