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Issue 6, 2015
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Na0.3WO3 nanorods: a multifunctional agent for in vivo dual-model imaging and photothermal therapy of cancer cells

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Abstract

The combination of imaging diagnosis and photothermal ablation (PTA) therapy has become a potential treatment for cancer. In particular, tungsten bronzes have a number of unique properties such as broad near-infrared (NIR) absorption and a large X-ray attenuation coefficient. However, these materials have seldom been reported as an X-ray computed tomography (CT) contrast agent and a photothermal agent. Herein, we synthesized PEGylated Na0.3WO3 nanorods (mean size ∼39 nm × 5 nm) by a simple one-pot solvothermal route. As we expected, the prepared PEGylated Na0.3WO3 nanorods exhibit intense NIR absorption, derived from the outer d-electron of W5+. These PEGylated Na0.3WO3 nanorods also show an excellent CT imaging effect and a high HU value of 29.95 HU g L−1 (much higher than the figure of iopamidol (19.35 HU g L−1)), due to the intrinsic property of tungsten of large atomic number and X-ray attenuation coefficient. Furthermore, the temperature elevation and the in vivo photothermal experiment reveal that as-synthesized Na0.3WO3 nanorods could be an effective photothermal agent, as they have low toxicity, high effectiveness and good photostability.

Graphical abstract: Na0.3WO3 nanorods: a multifunctional agent for in vivo dual-model imaging and photothermal therapy of cancer cells

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Supplementary files

Article information


Submitted
23 Sep 2014
Accepted
13 Nov 2014
First published
18 Nov 2014

Dalton Trans., 2015,44, 2771-2779
Article type
Paper

Na0.3WO3 nanorods: a multifunctional agent for in vivo dual-model imaging and photothermal therapy of cancer cells

Y. Zhang, B. Li, Y. Cao, J. Qin, Z. Peng, Z. Xiao, X. Huang, R. Zou and J. Hu, Dalton Trans., 2015, 44, 2771
DOI: 10.1039/C4DT02927E

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