Issue 1, 2015

The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2′′-terpyridine)platinum(ii) complexes

Abstract

Dinuclear (2,2′:6′,2′′-terpyridine)platinum(II) (PtTerpy) complexes were synthesised by tethering either thiol or pyridine based linkers. All intermediates and resulting complexes were characterised using a combination of 1H and 195Pt NMR, two-dimensional 1H correlation spectroscopy (NOSY/COSY), two-dimensional 1H/195Pt heteronuclear multiple bond correlation spectroscopy (HMQC), elemental analysis and electrospray ionisation mass spectrometry (ESI-MS). The cytotoxicity of the complexes was determined against human A2780 ovarian carcinoma cells and its cisplatin-resistant sub-line A2780cis, as well as L1210 murine leukemia cells.

Graphical abstract: The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2′′-terpyridine)platinum(ii) complexes

Supplementary files

Article information

Article type
Communication
Submitted
10 Sep 2014
Accepted
10 Nov 2014
First published
10 Nov 2014

Dalton Trans., 2015,44, 87-96

Author version available

The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2′′-terpyridine)platinum(II) complexes

B. W. J. Harper and J. R. Aldrich-Wright, Dalton Trans., 2015, 44, 87 DOI: 10.1039/C4DT02773F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements