Issue 6, 2015

A self-assembling lanthanide molecular nanoparticle for optical imaging

Abstract

Chromophores that incorporate f-block elements have considerable potential for use in bioimaging applications because of their advantageous photophysical properties compared to organic dye, which are currently widely used. We are developing new classes of lanthanide-based self-assembling molecular nanoparticles as reporters for imaging and as multi-functional nanoprobes or nanosensors for use with biological samples. One class of these materials, which we call lanthanide “nano-drums”, are homogeneous 4d–4f clusters approximately 25 to 30 Å in diameter. These are capable of emitting from the visible to near-infrared wavelengths. Here, we present the synthesis, crystal structure, photophysical properties and comparative cytotoxicity data for a 32 metal Eu-Cd nano-drum [Eu8Cd24L12(OAc)48] (1). We also explored the imaging capabilities of this nano-drum using epifluorescence, TIRF, and two-photon microscopy platforms.

Graphical abstract: A self-assembling lanthanide molecular nanoparticle for optical imaging

Supplementary files

Article information

Article type
Paper
Submitted
29 Aug 2014
Accepted
02 Dec 2014
First published
02 Dec 2014

Dalton Trans., 2015,44, 2667-2675

Author version available

A self-assembling lanthanide molecular nanoparticle for optical imaging

K. A. Brown, X. Yang, D. Schipper, J. W. Hall, L. J. DePue, A. J. Gnanam, J. F. Arambula, J. N. Jones, J. Swaminathan, Y. Dieye, J. Vadivelu, D. J. Chandler, E. M. Marcotte, J. L. Sessler, L. I. R. Ehrlich and R. A. Jones, Dalton Trans., 2015, 44, 2667 DOI: 10.1039/C4DT02646B

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