Issue 3, 2015
From the journal:

Catalysis Science & Technology

Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution†

Alba Díaz-Rodríguez,*a   Nicolás Ríos-Lombardía,a   Johann H. Sattler,b   Iván Lavandera,a   Vicente Gotor-Fernández,a   Wolfgang Kroutilb  and  Vicente Gotor*a  

* Corresponding authors

a Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, Instituto Universitario de Biotecnología de Asturias, Avenida Julián Clavería 8, 33006 Oviedo, Spain
E-mail: alba.x.diaz-rodriguez@gsk.com, vgs@uniovi.es

b Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria

Abstract

A mild one-pot methodology has been developed to deracemise rac-2-phenyl-1-propanol by combining the use of non-selective laccase/TEMPO-mediated oxidation with enantioselective bioreduction of the racemic aldehyde intermediate under dynamic conditions. The process was easily scalable and stereocontrollable by selecting the suitable biocatalyst.

Graphical abstract: Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

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Article information

DOI
https://doi.org/10.1039/C4CY01351D
Article type
Communication
Submitted
15 Oct 2014
Accepted
21 Jan 2015
First published
22 Jan 2015
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2015,5, 1443-1446

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Deracemisation of profenol core by combining laccase/TEMPO-mediated oxidation and alcohol dehydrogenase-catalysed dynamic kinetic resolution

A. Díaz-Rodríguez, N. Ríos-Lombardía, J. H. Sattler, I. Lavandera, V. Gotor-Fernández, W. Kroutil and V. Gotor, Catal. Sci. Technol., 2015, 5, 1443 DOI: 10.1039/C4CY01351D

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