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Issue 2, 2015
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Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

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Abstract

Proline has been grafted onto silica supports in a single step by reacting trans-4-hydroxy-L-proline with chloropropyl tethers, without the use of protecting groups for the proline amine and carboxylic acid functional groups. The resulting catalysts have been characterised to show that grafting is through reaction with the 4-hydroxy group. The catalysts have been tested in an asymmetric aldol reaction, and shown to be both more active and more enantioselective than equivalent catalysts prepared using a protection/deprotection route for the proline grafting step.

Graphical abstract: Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

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Supplementary files

Article information


Submitted
25 Jul 2014
Accepted
11 Sep 2014
First published
11 Sep 2014

Catal. Sci. Technol., 2015,5, 690-696
Article type
Paper
Author version available

Efficient synthesis of supported proline catalysts for asymmetric aldol reactions

A. A. Elmekawy, J. B. Sweeney and D. R. Brown, Catal. Sci. Technol., 2015, 5, 690
DOI: 10.1039/C4CY00970C

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