Ying Xie, Hongjie Pan, Mao Liu, Xiao Xiao and Yian Shi
Chem. Soc. Rev., 2015,44, 1740-1748
DOI:
10.1039/C4CS00507D,
Tutorial Review
Transamination of α-keto acids with transaminases and pyridoxamine phosphate is an important process to form optically active α-amino acids in biological systems. Various biomimetic transamination systems have been developed for carbonyl compounds including α-keto acid derivatives, fluoroalkyl ketones, and unactivated ketones with chiral vitamin B6 analogues, artificial transaminase mimics, chiral nitrogen sources, and chiral catalysts. This review provides a brief summary of this area.
