Jump to main content
Jump to site search

Issue 11, 2015
Previous Article Next Article

Macrocyclic amphiphiles

Author affiliations


In this critical review, we summarize recent results in the investigation of macrocyclic amphiphiles, amphiphiles based on macrocyclic frameworks. These interesting molecules have drawn a lot of attention over the past decades due to their unique superiority in self-assembly processes and other advantages. Compared with traditional linear amphiphiles, macrocyclic amphiphiles can be tailored to promote their self-assembly into various well-defined architectures by locating hydrophilic and hydrophobic chains on the respective sides. Since macrocyclic amphiphiles can be regarded as “surfactants” with host–guest recognition sites, they may be highly beneficial for applications where guest molecules must be stabilized, transported or protected in aqueous media. Considering the abundant research results on the host–guest chemistry of macrocycles, the use of macrocyclic amphiphiles in the fabrication of multidimensional and hierarchical self-assemblies may also provide interesting new topological structures. Moreover, the interactions of their self-assemblies can be mediated by molecular recognition, which may further our understanding of biological processes.

Graphical abstract: Macrocyclic amphiphiles

Back to tab navigation

Publication details

The article was received on 14 Nov 2014 and first published on 14 Apr 2015

Article type: Review Article
DOI: 10.1039/C4CS00390J
Citation: Chem. Soc. Rev., 2015,44, 3568-3587
  •   Request permissions

    Macrocyclic amphiphiles

    K. Jie, Y. Zhou, Y. Yao and F. Huang, Chem. Soc. Rev., 2015, 44, 3568
    DOI: 10.1039/C4CS00390J

Search articles by author