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Issue 8, 2015
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Investigating the role of human serum albumin protein pocket on the excited state dynamics of indocyanine green using shaped femtosecond laser pulses

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Abstract

Differences in the excited state dynamics of molecules and photo-activated drugs either in solution or confined inside protein pockets or large biological macromolecules occur within the first few hundred femtoseconds. Shaped femtosecond laser pulses are used to probe the behavior of indocyanine green (ICG), the only Food and Drug Administration (FDA) approved near-infrared dye and photodynamic therapy agent, while free in solution and while confined inside the pocket of the human serum albumin (HSA) protein. Experimental findings indicate that the HSA pocket hinders torsional motion and thus mitigates the triplet state formation in ICG. Low frequency vibrational motion of ICG is observed more clearly when it is bound to the HSA protein.

Graphical abstract: Investigating the role of human serum albumin protein pocket on the excited state dynamics of indocyanine green using shaped femtosecond laser pulses

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Article information


Submitted
30 Oct 2014
Accepted
20 Jan 2015
First published
21 Jan 2015

Phys. Chem. Chem. Phys., 2015,17, 5872-5877
Article type
Paper

Investigating the role of human serum albumin protein pocket on the excited state dynamics of indocyanine green using shaped femtosecond laser pulses

M. Nairat, A. Konar, M. Kaniecki, V. V. Lozovoy and M. Dantus, Phys. Chem. Chem. Phys., 2015, 17, 5872
DOI: 10.1039/C4CP04984E

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