Issue 35, 2015
From the journal:

CrystEngComm

The role of surface chemistry in crystal morphology and its associated properties†

Dinesh Kumar,a   Rajesh Thipparaboina,a   Bojja Sreedharb  and  Nalini R. Shastri*a  

* Corresponding authors

a Department of Pharmaceutics, NIPER (National Institute of Pharmaceutical Education & Research), Balanagar, Hyderabad, India
E-mail: nalini@niperhyd.ac.in, svcphod@yahoo.co.in
Fax: +91 040 23073751
Tel: +91 040 23423749

b Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, India

Abstract

Acetonitrile induced a remarkable enhancement of the {11−1} crystal facet of felodipine. This facet was polar in nature as concluded from surface chemistry determination and resulted in significant improvement in the dissolution rate and oral bioavailability (p < 0.05). This conclusion was supported with surface chemistry determination by X-ray photoelectron spectroscopy and Hirshfeld surface analysis.

Graphical abstract: The role of surface chemistry in crystal morphology and its associated properties

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Article information

DOI
https://doi.org/10.1039/C5CE01182E
Article type
Communication
Submitted
17 Jun 2015
Accepted
05 Aug 2015
First published
06 Aug 2015

CrystEngComm, 2015,17, 6646-6650

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The role of surface chemistry in crystal morphology and its associated properties

D. Kumar, R. Thipparaboina, B. Sreedhar and N. R. Shastri, CrystEngComm, 2015, 17, 6646 DOI: 10.1039/C5CE01182E

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