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Issue 72, 2015
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A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity

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Abstract

A sensitive and selective assay of uracil DNA glycosylase (UDG) activity is developed by utilizing a G-quadruplex probe incorporating 2-aminopurine (2-AP), based on a novel design that excision reaction promoted by UDG triggers the formation of G-quadruplex structure with significant fluorescence enhancement of 2-AP within the probe.

Graphical abstract: A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity

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Publication details

The article was received on 17 Jun 2015, accepted on 20 Jul 2015 and first published on 20 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC05010C
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Citation: Chem. Commun., 2015,51, 13744-13747

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    A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity

    C. Y. Lee, K. S. Park and H. G. Park, Chem. Commun., 2015, 51, 13744
    DOI: 10.1039/C5CC05010C

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