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Issue 65, 2015
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Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

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Abstract

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

Graphical abstract: Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

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Supplementary files

Article information


Submitted
05 Jun 2015
Accepted
07 Jul 2015
First published
08 Jul 2015

This article is Open Access

Chem. Commun., 2015,51, 12977-12980
Article type
Communication
Author version available

Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

D. E. Mitchell, N. R. Cameron and M. I. Gibson, Chem. Commun., 2015, 51, 12977
DOI: 10.1039/C5CC04647E

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