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Issue 59, 2015
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[11C]CO2 to [11C]CO conversion mediated by [11C]silanes: a novel route for [11C]carbonylation reactions

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Abstract

A novel chemical methodology is described for the conversion of [11C]CO2 to [11C]CO. Diphenylmethyl silanes trap [11C]CO2 and release [11C]CO rapidly when triggered by TBAF. Released [11C]CO was used to produce [11C]N-benzylbenzamide and AMPA receptor ligand, [11C]CX546, in radiochemical yields >90% within 6 min from [11C]CO2 production.

Graphical abstract: [11C]CO2 to [11C]CO conversion mediated by [11C]silanes: a novel route for [11C]carbonylation reactions

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Publication details

The article was received on 11 Mar 2015, accepted on 12 Jun 2015 and first published on 12 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC02095F
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Citation: Chem. Commun., 2015,51, 11795-11797

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    [11C]CO2 to [11C]CO conversion mediated by [11C]silanes: a novel route for [11C]carbonylation reactions

    C. Taddei, S. Bongarzone, A. K. Haji Dheere and A. D. Gee, Chem. Commun., 2015, 51, 11795
    DOI: 10.1039/C5CC02095F

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