Issue 35, 2015

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Abstract

A simple supramolecular hydrogel based on 1,3:2,4-di(4-acylhydrazide)benzylidene sorbitol (DBS-CONHNH2), is able to extract acid-functionalised anti-inflammatory drugs via directed interactions with the self-assembled gel nanofibres. Two-component hydrogel-drug hybrid materials can be easily formed by mixing and exhibit pH-controlled drug release.

Graphical abstract: Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

Supplementary files

Article information

Article type
Communication
Submitted
04 Mar 2015
Accepted
19 Mar 2015
First published
31 Mar 2015

Chem. Commun., 2015,51, 7451-7454

Author version available

Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients

E. J. Howe, B. O. Okesola and D. K. Smith, Chem. Commun., 2015, 51, 7451 DOI: 10.1039/C5CC01868D

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