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Issue 41, 2015
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Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides

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Abstract

We identify a new amyloidogenic peptide from the glutamine/asparagine-rich region of the FTLD-related protein (TDP-43), which can seed both the full-length and N-terminus-truncated TDP-43. Through the microinjection and real-time fluorescence imaging, we also found that this novel peptide could trigger cell apoptosis and initiate TDP-43 aggregation in the cytosol.

Graphical abstract: Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides

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Publication details

The article was received on 19 Jan 2015, accepted on 08 Apr 2015 and first published on 14 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC00513B
Chem. Commun., 2015,51, 8652-8655

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    Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides

    R. He, Y. Huang, C. Chiang, Y. Tsai, T. Ye, H. Gao, C. Wu, H. Lee and J. J. Huang, Chem. Commun., 2015, 51, 8652
    DOI: 10.1039/C5CC00513B

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