A novel biomimetic approach to optically active α-aminophosphonates utilizing readily available acylphosphonates and 2-chlorobenzylamine as starting materials has been described. The enantioselective protonation constitutes the main enantiodifferentiating step in the developed strategy. This nature-inspired approach proceeds efficiently and in a highly stereoselective manner.
D. Kowalczyk and Ł. Albrecht, Chem. Commun., 2015, 51, 3981 DOI: 10.1039/C4CC09477H
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