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Issue 25, 2015
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A modular DNA origami-based enzyme cascade nanoreactor

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Abstract

In this communication, we present a nanoscale reactor assembled from tuneable and spatially addressable tubular DNA origami units. We can controllably combine separate origami units equipped with glucose oxidase (GOx) and horseradish peroxidase (HRP), and demonstrate efficient GOx/HRP enzyme cascade reaction inside the tube. The reactor could be utilized as a nanoscale diagnostic tool, and modularity of the proposed system would further enable more complex reactions.

Graphical abstract: A modular DNA origami-based enzyme cascade nanoreactor

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Supplementary files

Article information


Submitted
27 Oct 2014
Accepted
11 Jan 2015
First published
12 Jan 2015

This article is Open Access

Chem. Commun., 2015,51, 5351-5354
Article type
Communication
Author version available

A modular DNA origami-based enzyme cascade nanoreactor

V. Linko, M. Eerikäinen and M. A. Kostiainen, Chem. Commun., 2015, 51, 5351
DOI: 10.1039/C4CC08472A

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