Issue 14, 2015

Catalytic SNAr of unactivated aryl chlorides


We present nucleophilic aromatic substitution of unsubstituted aryl chlorides via a mechanism that is catalytic in [CpRu(p-cymene)]PF6 and involves a Ru(η6-arylchloride) intermediate. From the spectroscopic evidence we infer that arene exchange is the rate limiting step in this process and develop several new Ru(II) complexes that lower the activation barrier to arene exchange.

Graphical abstract: Catalytic SNAr of unactivated aryl chlorides

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Article information

Article type
09 Sep 2014
06 Oct 2014
First published
06 Oct 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 2786-2789

Author version available

Catalytic SNAr of unactivated aryl chlorides

J. W. Walton and J. M. J. Williams, Chem. Commun., 2015, 51, 2786 DOI: 10.1039/C4CC07116F

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