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Issue 99, 2015
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Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

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Abstract

Self-assembled cholesterol–asplatin-incorporated nanoparticles (SCANs) were prepared for oral delivery of a Pt(IV) prodrug. SCANs exhibit high gastrointestinal stability, sustained drug release and enhanced cell uptake. The oral bioavailability of SCANs was 4.32-fold higher than that of free Pt(IV) prodrugs. The oral administration of SCANs efficaciously inhibits tumor growth with negligible toxicity.

Graphical abstract: Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

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Supplementary files

Article information


Submitted
18 Sep 2015
Accepted
09 Oct 2015
First published
12 Oct 2015

Chem. Commun., 2015,51, 17536-17539
Article type
Communication
Author version available

Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

Q. Cheng, H. Shi, H. Huang, Z. Cao, J. Wang and Y. Liu, Chem. Commun., 2015, 51, 17536
DOI: 10.1039/C5CC07853A

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