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Issue 99, 2015
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Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

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Abstract

Self-assembled cholesterol–asplatin-incorporated nanoparticles (SCANs) were prepared for oral delivery of a Pt(IV) prodrug. SCANs exhibit high gastrointestinal stability, sustained drug release and enhanced cell uptake. The oral bioavailability of SCANs was 4.32-fold higher than that of free Pt(IV) prodrugs. The oral administration of SCANs efficaciously inhibits tumor growth with negligible toxicity.

Graphical abstract: Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

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The article was received on 18 Sep 2015, accepted on 09 Oct 2015 and first published on 12 Oct 2015


Article type: Communication
DOI: 10.1039/C5CC07853A
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Citation: Chem. Commun., 2015,51, 17536-17539
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    Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

    Q. Cheng, H. Shi, H. Huang, Z. Cao, J. Wang and Y. Liu, Chem. Commun., 2015, 51, 17536
    DOI: 10.1039/C5CC07853A

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