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Issue 83, 2015
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Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

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Abstract

Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free “click” assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.

Graphical abstract: Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

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Submitted
19 Aug 2015
Accepted
24 Aug 2015
First published
24 Aug 2015

Chem. Commun., 2015,51, 15304-15307
Article type
Communication

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

A. Maruani, H. Savoie, F. Bryden, S. Caddick, R. Boyle and V. Chudasama, Chem. Commun., 2015, 51, 15304
DOI: 10.1039/C5CC06985H

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