A new strategy for the fabrication of glycosaminoglycan (GAG) analogs was proposed by copolymerizing the sulfonated unit and the glyco unit, ‘splitted’ from the sulfated saccharide building blocks of GAGs. The synthetic polymers can promote cell proliferation and neural differentiation of embryonic stem cells with the effects even better than those of heparin.
M. Wang, Z. Lyu, G. Chen, H. Wang, Y. Yuan, K. Ding, Q. Yu, L. Yuan and H. Chen, Chem. Commun., 2015, 51, 15434 DOI: 10.1039/C5CC06944K
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