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Issue 96, 2015
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Highly-efficient and versatile fluorous-tagged Cu(I)-catalyzed azide–alkyne cycloaddition ligand for preparing bioconjugates

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Abstract

A novel ligand (FBTTBE) for Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(I) catalyst.

Graphical abstract: Highly-efficient and versatile fluorous-tagged Cu(i)-catalyzed azide–alkyne cycloaddition ligand for preparing bioconjugates

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Publication details

The article was received on 14 Aug 2015, accepted on 25 Sep 2015 and first published on 25 Sep 2015


Article type: Communication
DOI: 10.1039/C5CC06858D
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Citation: Chem. Commun., 2015,51, 17072-17075
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    Highly-efficient and versatile fluorous-tagged Cu(I)-catalyzed azide–alkyne cycloaddition ligand for preparing bioconjugates

    L. Sun, Y. Gai, C. J. Anderson and D. Zeng, Chem. Commun., 2015, 51, 17072
    DOI: 10.1039/C5CC06858D

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