Issue 85, 2015

Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents

Abstract

Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce phototoxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).

Graphical abstract: Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents

Supplementary files

Article information

Article type
Communication
Submitted
05 Aug 2015
Accepted
26 Aug 2015
First published
26 Aug 2015

Chem. Commun., 2015,51, 15550-15553

Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents

N. Venkatramaiah, P. M. R. Pereira, F. A. Almeida Paz, C. A. F. Ribeiro, R. Fernandes and J. P. C. Tomé, Chem. Commun., 2015, 51, 15550 DOI: 10.1039/C5CC06561E

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