Issue 87, 2015

Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides

Abstract

An efficient one-pot approach for the synthesis of spiro[2.5]octa-4,7-dien-6-ones by employing para-quinone methides has been developed. The reaction proceeded smoothly in high yields under mild conditions without the use of metals. Moreover, all products obtained herein contained two or three consecutive quaternary centers.

Graphical abstract: Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides

Supplementary files

Article information

Article type
Communication
Submitted
27 Jul 2015
Accepted
04 Sep 2015
First published
04 Sep 2015

Chem. Commun., 2015,51, 15831-15834

Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides

K. Gai, X. Fang, X. Li, J. Xu, X. Wu, A. Lin and H. Yao, Chem. Commun., 2015, 51, 15831 DOI: 10.1039/C5CC06287J

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