Issue 81, 2015
From the journal:

Chemical Communications

N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides†‡

Vikas Dwivedi,§a   Madala Hari Babu,§a   Ruchir Kantb  and  Maddi Sridhar Reddy*ac  

* Corresponding authors

a Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram extension, Sitapur Road, Lucknow 226031, India
E-mail: msreddy@cdri.res.in

b Molecular & Structural Biology Division, CSIR-CDRI, Lucknow 226031, India

c Academy of Scientific and Innovative Research, New Delhi 110001, India

Abstract

A highly general palladium catalysed regioselective hydroalkynylation of ynamides for versatile enamide building blocks with an alkyne tether is achieved with an N-substitution dependent stereoselectivity switch under very mild reaction conditions.

Graphical abstract: N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides

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Article information

DOI
https://doi.org/10.1039/C5CC06251A
Article type
Communication
Submitted
26 Jul 2015
Accepted
11 Aug 2015
First published
12 Aug 2015

Chem. Commun., 2015,51, 14996-14999

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N-Substitution dependent stereoselectivity switch in palladium catalyzed hydroalkynylation of ynamides: a regio and stereoselective synthesis of ynenamides

V. Dwivedi, M. Hari Babu, R. Kant and M. Sridhar Reddy, Chem. Commun., 2015, 51, 14996 DOI: 10.1039/C5CC06251A

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