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Issue 80, 2015
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Enzyme-responsive pillar[5]arene-based polymer-substituted amphiphiles: synthesis, self-assembly in water, and application in controlled drug release

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Abstract

An enzyme-responsive drug delivery system was constructed from a pillar[5]arene-based polyethyleneglycol-substituted amphiphile which self-assembles into micelles in water. These micelles exhibit superior drug encapsulation capability, and display drug release behaviour in response to enzyme catalysis, in particular to L-asparaginase. Doxorubicin-loaded micelles show significant cytotoxicity against MCF-7 cancer cells.

Graphical abstract: Enzyme-responsive pillar[5]arene-based polymer-substituted amphiphiles: synthesis, self-assembly in water, and application in controlled drug release

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Publication details

The article was received on 24 Jul 2015, accepted on 14 Aug 2015 and first published on 14 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC06207A
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Chem. Commun., 2015,51, 14901-14904

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    Enzyme-responsive pillar[5]arene-based polymer-substituted amphiphiles: synthesis, self-assembly in water, and application in controlled drug release

    L. Gao, B. Zheng, W. Chen and C. A. Schalley, Chem. Commun., 2015, 51, 14901
    DOI: 10.1039/C5CC06207A

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