Issue 95, 2015
From the journal:

Chemical Communications

Light-triggered chemical amplification to accelerate degradation and release from polymeric particles†

Jason Olejniczak,a   Viet Anh Nguyen Huu,b   Jacques Lux,c   Madeleine Grossman,‡a   Sha Heb  and  Adah Almutairi*bcd  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA

b Department of NanoEngineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA
E-mail: aalmutairi@ucsd.edu

c Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA

d Department of Materials Science and Engineering, KACST-UCSD Center of Excellence in Nanomedicine and Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, USA

Abstract

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

Graphical abstract: Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

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Article information

DOI
https://doi.org/10.1039/C5CC06143A
Article type
Communication
Submitted
27 Jul 2015
Accepted
25 Sep 2015
First published
28 Sep 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 16980-16983

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Light-triggered chemical amplification to accelerate degradation and release from polymeric particles

J. Olejniczak, V. A. Nguyen Huu, J. Lux, M. Grossman, S. He and A. Almutairi, Chem. Commun., 2015, 51, 16980 DOI: 10.1039/C5CC06143A

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