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Issue 93, 2015
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Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome

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Abstract

The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(β-A)SKKKKTKV-NH2 and a thiol substituted cRGD. NIR fluorescence imaging showed rapid cellular delivery of the CPP conjugate and effective in vivo tumour localization for the cRGD conjugate.

Graphical abstract: Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome

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Article information


Submitted
22 Jul 2015
Accepted
24 Sep 2015
First published
24 Sep 2015

Chem. Commun., 2015,51, 16667-16670
Article type
Communication
Author version available

Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome

D. Wu, S. Cheung, M. Devocelle, L. Zhang, Z. Chen and D. F. O'Shea, Chem. Commun., 2015, 51, 16667
DOI: 10.1039/C5CC06137G

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