Issue 78, 2015
From the journal:

Chemical Communications

Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide†

J.-M. Swiecicki,‡abc   M. Di Pisa,‡abc   F. Lippi,abc   S. Chwetzoff,acdef   C. Mansuy,abc   G. Trugnan,acde   G. Chassaing,abc   S. Lavielle*abc  and  F. Burlina*abc  

* Corresponding authors

a Sorbonne Universités, UPMC Univ Paris 06, Laboratoire des Biomolécules, UMR 7203, 4, Place Jussieu 75005, Paris, France
E-mail: solange.lavielle@upmc.fr, fabienne.burlina@upmc.fr

b Ecole Normale Supérieure – PSL Research University Institution, Département de Chimie, 24, Rue Lhomond, 75005 Paris, France

c CNRS – UMR7203, Paris, France

d INSERM – ERL 1157, Paris, France

e AP-HP, Hôpital Saint Antoine, 75012 Paris, France

f INRA, UR892, Virologie et Immunologie Moléculaires, 78350, Jouy-en-Jossas, France

Abstract

The recurring issue with cell penetrating peptides is how to increase direct translocation vs. endocytosis, to avoid premature degradation. Acylation by a cis unsaturated chain (C22:6) of a short cationic peptide provides a new rational design to favour diffuse cytosolic and dense Golgi localisations.

Graphical abstract: Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC06116D
Article type
Communication
Submitted
22 Jul 2015
Accepted
12 Aug 2015
First published
14 Aug 2015

Chem. Commun., 2015,51, 14656-14659

Author version available

Download author version (PDF)

Permissions

Request permissions

Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

J.-M. Swiecicki, M. Di Pisa, F. Lippi, S. Chwetzoff, C. Mansuy, G. Trugnan, G. Chassaing, S. Lavielle and F. Burlina, Chem. Commun., 2015, 51, 14656 DOI: 10.1039/C5CC06116D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements