Issue 81, 2015
From the journal:

Chemical Communications

A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake†

Tangjian Cheng,a   Rujiang Ma,a   Yumin Zhang,b   Yuxun Ding,a   Jinjian Liu,b   Hanlin Ou,a   Yingli An,a   Jianfeng Liub  and  Linqi Shi*a  

* Corresponding authors

a State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China
E-mail: shilinqi@nankai.edu.cn

b Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P. R. China

Abstract

Based on the protonation/deprotonation of poly(β-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5).

Graphical abstract: A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake

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Article information

DOI
https://doi.org/10.1039/C5CC05854F
Article type
Communication
Submitted
15 Jul 2015
Accepted
11 Aug 2015
First published
11 Aug 2015

Chem. Commun., 2015,51, 14985-14988

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A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake

T. Cheng, R. Ma, Y. Zhang, Y. Ding, J. Liu, H. Ou, Y. An, J. Liu and L. Shi, Chem. Commun., 2015, 51, 14985 DOI: 10.1039/C5CC05854F

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