Issue 93, 2015
From the journal:

Chemical Communications

Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo†

Roun Heo,a   Hong Yeol Yoon,b   Hyewon Ko,a   Jung Min Shin,b   Jueun Jeon,b   Yee Soo Chae,c   Young Mo Kang,c   Dukjoon Kim,b   Doo Sung Leeb  and  Jae Hyung Park*ab  

* Corresponding authors

a Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: jhpark1@skku.edu
Fax: +82-31-292-8790
Tel: +82-31-290-7288

b School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea

c School of Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea

Abstract

The key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these issues, we developed gold-installed polyethyleneimine/siRNA complexes with a corona of PEGylated hyaluronic acid.

Graphical abstract: Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo

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Article information

DOI
https://doi.org/10.1039/C5CC05639J
Article type
Communication
Submitted
08 Jul 2015
Accepted
21 Sep 2015
First published
21 Sep 2015

Chem. Commun., 2015,51, 16656-16659

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Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo

R. Heo, H. Y. Yoon, H. Ko, J. M. Shin, J. Jeon, Y. S. Chae, Y. M. Kang, D. Kim, D. S. Lee and J. H. Park, Chem. Commun., 2015, 51, 16656 DOI: 10.1039/C5CC05639J

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