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Issue 92, 2015
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Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

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Abstract

The influence of RNA versus DNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.

Graphical abstract: Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

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Publication details

The article was received on 02 Jul 2015, accepted on 22 Sep 2015 and first published on 30 Sep 2015


Article type: Communication
DOI: 10.1039/C5CC05450H
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Citation: Chem. Commun., 2015,51, 16526-16529
  • Open access: Creative Commons BY-NC license
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    Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

    R. Tavallaie, N. Darwish, D. Brynn Hibbert and J. Justin Gooding, Chem. Commun., 2015, 51, 16526
    DOI: 10.1039/C5CC05450H

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