Issue 86, 2015

Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections

Abstract

Achieving selective and sensitive carbohydrate–protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggregation revealed that the large number of surface interactions of rod shaped mannose-AuNPs with E. coli ORN 178 compared with spherical and star-shaped AuNPs exhibited higher avidity and sensitivity. Moreover, such sensitive binding can be used for effective inhibition of bacterial infection of cells.

Graphical abstract: Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections

Supplementary files

Article information

Article type
Communication
Submitted
25 Jun 2015
Accepted
28 Aug 2015
First published
28 Aug 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 15669-15672

Author version available

Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections

P. M. Chaudhary, S. Sangabathuni, R. V. Murthy, A. Paul, H. V. Thulasiram and R. Kikkeri, Chem. Commun., 2015, 51, 15669 DOI: 10.1039/C5CC05238F

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