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Issue 75, 2015
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Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction

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Abstract

The facile synthesis of the cage molecule (C110H56Br2) via a remarkable three-fold homo-coupling macrocyclization reaction using continuous flow methodology is reported. Synthesis via continuous flow chemistry improves the residence time, safety, and environmental profile of this synthetically challenging reaction. Further, the new cage possesses halogen atoms at its apex that serve to expand the potential reaction space of these intrinsically porous, all carbon–carbon bonded molecular cage molecules.

Graphical abstract: Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction

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Publication details

The article was received on 24 Jun 2015, accepted on 01 Aug 2015 and first published on 03 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC05181A
Citation: Chem. Commun., 2015,51, 14231-14234
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    Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction

    M. Kitchin, K. Konstas, C. J. Sumby, M. L. Czyz, P. Valente, M. R. Hill, A. Polyzos and C. J. Doonan, Chem. Commun., 2015, 51, 14231
    DOI: 10.1039/C5CC05181A

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