Issue 69, 2015

A BODIPY-based ‘turn-on’ fluorescent probe for hypoxic cell imaging

Abstract

A boron-dipyrromethene (BODIPY) dye containing a styryl substituent with a hydroxyl and nitro group, 1a, exhibits a ‘turn-on’ fluorescence response for hypoxic cells. The presence of the electron-withdrawing nitro group results in a highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence intensity when nitro reduction occurs under hypoxic conditions.

Graphical abstract: A BODIPY-based ‘turn-on’ fluorescent probe for hypoxic cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
23 Jun 2015
Accepted
13 Jul 2015
First published
13 Jul 2015

Chem. Commun., 2015,51, 13389-13392

A BODIPY-based ‘turn-on’ fluorescent probe for hypoxic cell imaging

S. Wang, H. Liu, J. Mack, J. Tian, B. Zou, H. Lu, Z. Li, J. Jiang and Z. Shen, Chem. Commun., 2015, 51, 13389 DOI: 10.1039/C5CC05139H

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