Issue 69, 2015
From the journal:

Chemical Communications

A BODIPY-based ‘turn-on’ fluorescent probe for hypoxic cell imaging†

Sisi Wang,‡a   Hui Liu,‡a   John Mack,c   Jiangwei Tian,b   Bin Zou,a   Hua Lu,*a   Zhifang Li,a   Jianxiong Jianga  and  Zhen Shen*b  

* Corresponding authors

a Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, P. R. China
E-mail: hualu@hznu.edu.cn

b State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China
E-mail: zshen@nju.edu.cn

c Department of Chemistry, Rhodes University, Grahamstown, South Africa

Abstract

A boron-dipyrromethene (BODIPY) dye containing a styryl substituent with a hydroxyl and nitro group, 1a, exhibits a ‘turn-on’ fluorescence response for hypoxic cells. The presence of the electron-withdrawing nitro group results in a highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence intensity when nitro reduction occurs under hypoxic conditions.

Graphical abstract: A BODIPY-based ‘turn-on’ fluorescent probe for hypoxic cell imaging

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Article information

DOI
https://doi.org/10.1039/C5CC05139H
Article type
Communication
Submitted
23 Jun 2015
Accepted
13 Jul 2015
First published
13 Jul 2015

Chem. Commun., 2015,51, 13389-13392

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A BODIPY-based ‘turn-on’ fluorescent probe for hypoxic cell imaging

S. Wang, H. Liu, J. Mack, J. Tian, B. Zou, H. Lu, Z. Li, J. Jiang and Z. Shen, Chem. Commun., 2015, 51, 13389 DOI: 10.1039/C5CC05139H

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