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Issue 69, 2015
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Iron-catalyzed direct α-arylation of ethers with azoles

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Abstract

The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process. This practical oxidative method allowed the efficient C2-alkylation of a variety of (benzo)azoles constituting straightforward access to heterocycles of utmost medicinal significance and highlighting the convenient use of feedstock substrates and iron catalysts. A preliminary mechanism supported by DFT calculations is discussed as well.

Graphical abstract: Iron-catalyzed direct α-arylation of ethers with azoles

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Publication details

The article was received on 17 Jun 2015, accepted on 12 Jul 2015 and first published on 14 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC05005G
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Chem. Commun., 2015,51, 13365-13368
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    Iron-catalyzed direct α-arylation of ethers with azoles

    A. Correa, B. Fiser and E. Gómez-Bengoa, Chem. Commun., 2015, 51, 13365
    DOI: 10.1039/C5CC05005G

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