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Issue 78, 2015
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A biosensor for the detection of single base mismatches in microRNA

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Abstract

Graphene oxide quenches fluorescence corresponding to only a mismatched target due to selective denaturing of the thermo-unstable duplex composed of probe peptide nucleic acid and single base mismatched target RNA and thus, the fluorescence signal only from perfectly matched target RNA is measured.

Graphical abstract: A biosensor for the detection of single base mismatches in microRNA

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Supplementary files

Article information


Submitted
09 Jun 2015
Accepted
05 Aug 2015
First published
05 Aug 2015

Chem. Commun., 2015,51, 14597-14600
Article type
Communication

A biosensor for the detection of single base mismatches in microRNA

J. Lee, G. Park and D. Min, Chem. Commun., 2015, 51, 14597
DOI: 10.1039/C5CC04706D

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