Issue 71, 2015
From the journal:

Chemical Communications

Double clicking for site-specific coupling of multiple enzymes†

Sung In Lim,a   Jinhwan Chob  and  Inchan Kwon*ab  

* Corresponding authors

a Department of Chemical Engineering, University of Virginia, 102 Engineers' Way, Charlottesville, VA 22904, USA

b School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), 123 Cheomdan Gwagi-ro, Buk-gu, Gwangju, Republic of Korea
E-mail: inchan@gist.ac.kr
Fax: +82-62-715-2304
Tel: +82-62-715-2312

Abstract

A method to site-specifically couple multiple enzymes is reported. The approach is based on the site-specific incorporation of a clickable non-natural amino acid into enzymes and two compatible click reactions. The multi-enzyme reaction system exhibited enhanced catalytic efficiency over the respective free enzymes.

Graphical abstract: Double clicking for site-specific coupling of multiple enzymes

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Article information

DOI
https://doi.org/10.1039/C5CC04611D
Article type
Communication
Submitted
04 Jun 2015
Accepted
02 Jul 2015
First published
02 Jul 2015

Chem. Commun., 2015,51, 13607-13610

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Double clicking for site-specific coupling of multiple enzymes

S. I. Lim, J. Cho and I. Kwon, Chem. Commun., 2015, 51, 13607 DOI: 10.1039/C5CC04611D

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