Gd3+ is increasingly used in EPR spectroscopy due to its increased intracellular stability and signal-to-noise ratios. Here we present the incorporation of Gd3+-DOTA into internal positions in DNA. Distance measurements via pulsed Electron Paramagnetic Resonance (EPR) spectroscopy in vitro and in cellula proved enhanced stability and efficiency compared to nitroxide labels.
F. Wojciechowski, A. Groß, I. T. Holder, L. Knörr, M. Drescher and J. S. Hartig, Chem. Commun., 2015, 51, 13850 DOI: 10.1039/C5CC04234H
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