A novel method of enantioselective 1,3-dioxane construction via a hemiacetalization/intramolecular oxy-Michael addition cascade by a chiral phosphoric acid catalyst was developed. The product was successfully transformed into an optically active 1,3-polyol motif, indicating that the proposed reaction can provide useful chiral building blocks for the de novo synthesis of polyketides.
A. Matsumoto, K. Asano and S. Matsubara, Chem. Commun., 2015, 51, 11693 DOI: 10.1039/C5CC04124D
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