Jump to main content
Jump to site search

Issue 59, 2015
Previous Article Next Article

Direct photocatalytic fluorination of benzylic C–H bonds with N-fluorobenzenesulfonimide

Author affiliations

Abstract

The late-stage fluorination of common synthetic building blocks and drug leads is an appealing reaction for medicinal chemistry. In particular, fluorination of benzylic C–H bonds provides a means to attenuate drug metabolism at this metabolically labile position. Here we report two complimentary strategies for the direct fluorination of benzylic C–H bonds using N-fluorobenzenesulfonimide and either a decatungstate photocatalyst or AIBN-initiation.

Graphical abstract: Direct photocatalytic fluorination of benzylic C–H bonds with N-fluorobenzenesulfonimide

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 May 2015, accepted on 15 Jun 2015 and first published on 24 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC04058B
Author version
available:
Download author version (PDF)
Chem. Commun., 2015,51, 11783-11786

  •   Request permissions

    Direct photocatalytic fluorination of benzylic C–H bonds with N-fluorobenzenesulfonimide

    M. B. Nodwell, A. Bagai, S. D. Halperin, R. E. Martin, H. Knust and R. Britton, Chem. Commun., 2015, 51, 11783
    DOI: 10.1039/C5CC04058B

Search articles by author

Spotlight

Advertisements