A pillar[5]arene-based bioactive guest loading system has been developed, which can increase the solubility of the drug norharmane in aqueous medium, and also enable its pH-stimulated release. Furthermore, this supramolecular transport system reduces the toxicity of loaded guest.
![Graphical abstract: Supramolecular hydrophobic guest transport system based on pillar[5]arene](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC03955J&imageInfo.ImageIdentifier.Year=2015)
Z. Qi, K. Achazi, R. Haag, S. Dong and C. A. Schalley, Chem. Commun., 2015, 51, 10326 DOI: 10.1039/C5CC03955J
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