Issue 53, 2015

An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles

Abstract

An efficient and unprecedented domino reaction of methyleneindolinones and N-tosyloxycarbamates has been developed to afford structurally complex and diverse bispirooxindoles in excellent yields (up to 98%) and spiroaziridine oxindoles in moderate to good yields (55–91%). Moreover, this protocol could also provide the unsymmetrical bispirooxindoles and various fused spirocyclic pyrrolidines in excellent yields.

Graphical abstract: An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles

Supplementary files

Article information

Article type
Communication
Submitted
07 May 2015
Accepted
21 May 2015
First published
01 Jun 2015

Chem. Commun., 2015,51, 10726-10729

An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles

Q. Wang, T. Cai, J. Zhou, F. Tian, X. Xu and L. Wang, Chem. Commun., 2015, 51, 10726 DOI: 10.1039/C5CC03793J

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