Issue 55, 2015
From the journal:

Chemical Communications

Ultrasensitive and feasibly achieved protein detection based on the integration of three signal amplification reactions via sharing a DNA sequence†

Yue Huang,a   Hao Li,a   Yuanyuan Zhang,b   Weiwei Li,a   Lizhou Sunb  and  Genxi Li*ac  

* Corresponding authors

a State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China
E-mail: genxili@nju.edu.cn
Fax: +86 25 83592510

b Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210036, P. R. China

c Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

Abstract

This communication reports a novel strategy for the detection of proteins based on the integration of three signal amplification reactions via sharing a specially designed DNA sequence. This strategy has been demonstrated by the assay of human TNF-α in the serum of ovarian cancer patients, showing potential clinical applications.

Graphical abstract: Ultrasensitive and feasibly achieved protein detection based on the integration of three signal amplification reactions via sharing a DNA sequence

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Article information

DOI
https://doi.org/10.1039/C5CC03700J
Article type
Communication
Submitted
04 May 2015
Accepted
26 May 2015
First published
26 May 2015

Chem. Commun., 2015,51, 11004-11007

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Ultrasensitive and feasibly achieved protein detection based on the integration of three signal amplification reactions via sharing a DNA sequence

Y. Huang, H. Li, Y. Zhang, W. Li, L. Sun and G. Li, Chem. Commun., 2015, 51, 11004 DOI: 10.1039/C5CC03700J

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