Issue 58, 2015
From the journal:

Chemical Communications

The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques†

Kaixiang Zhou,a   Hualong Fu,a   Liang Feng,a   Mengchao Cui,*a   Jiapei Daib  and  Boli Liua  

* Corresponding authors

a Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China
E-mail: cmc@bnu.edu.cn

b Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan 430074, P. R. China

Abstract

A new array of near-infrared probes containing barbituric acid acceptors has been developed as Aβ imaging agents. These probes displayed long-emission wavelengths and large Stokes shifts, as well as high affinities for Aβ aggregates. In vivo and ex vivo studies demonstrated that BBTOM-3 could intensely label Aβ plaques in the brains of transgenic mice.

Graphical abstract: The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques

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Article information

DOI
https://doi.org/10.1039/C5CC03662C
Article type
Communication
Submitted
02 May 2015
Accepted
09 Jun 2015
First published
09 Jun 2015

Chem. Commun., 2015,51, 11665-11668

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The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques

K. Zhou, H. Fu, L. Feng, M. Cui, J. Dai and B. Liu, Chem. Commun., 2015, 51, 11665 DOI: 10.1039/C5CC03662C

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