Issue 51, 2015
From the journal:

Chemical Communications

Alkyl–aryl ketone synthesis via nickel-catalyzed reductive coupling of alkyl halides with aryl acids and anhydrides†

Xiao Jia,a   Xinghua Zhang,*b   Qun Qian*a  and  Hegui Gong*a  

* Corresponding authors

a Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China
E-mail: hegui_gong@shu.edu.cn, qianqun@shu.edu.cn

b School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Hai-Quan Road, Shanghai 201418, China
E-mail: zxhxmu@126.com

Abstract

The present work disclosed a considerably improved method for the construction of alkyl–aryl ketones by the direct coupling of unactivated alkyl bromides with 1.5 equiv. of acids. In addition, the synthesis of aroyl C-glycosides was first achieved by the reductive coupling of 1-glycosyl bromides with acid derivatives, which may otherwise require multi-step synthesis.

Graphical abstract: Alkyl–aryl ketone synthesis via nickel-catalyzed reductive coupling of alkyl halides with aryl acids and anhydrides

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Article information

DOI
https://doi.org/10.1039/C5CC03113C
Article type
Communication
Submitted
15 Apr 2015
Accepted
14 May 2015
First published
14 May 2015

Chem. Commun., 2015,51, 10302-10305

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Alkyl–aryl ketone synthesis via nickel-catalyzed reductive coupling of alkyl halides with aryl acids and anhydrides

X. Jia, X. Zhang, Q. Qian and H. Gong, Chem. Commun., 2015, 51, 10302 DOI: 10.1039/C5CC03113C

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